Transcription Factor Classification
Superclasses & classes; last modified 2002-10-01

1 Superclass: Basic Domains

1.1 Class: Leucine zipper factors (bZIP)
1.2 Class: Helix-loop-helix factors (bHLH)
1.3 Class: Helix-loop-helix / leucine zipper factors (bHLH-ZIP).
1.4 Class: NF-1
1.5 Class: RF-X
1.6 Class: bHSH

2 Superclass: Zinc-coordinating DNA-binding domains

2.1 Class: Cys4 zinc finger of nuclear receptor type
2.2 Class: diverse Cys4 zinc fingers
2.3 Class: Cys2His2 zinc finger domain
2.4 Class: Cys6 cysteine-zinc cluster
2.5 Class: Zinc fingers of alternating composition

3 Superclass: Helix-turn-helix

3.1 Class: Homeo domain.
3.2 Class: Paired box
3.3 Class: Fork head / winged helix.
3.4 Class: Heat shock factors
3.5 Class: Tryptophan clusters
3.6 Class: TEA domain

4 Superclass: beta-Scaffold Factors with Minor Groove Contacts

4.1 Class: RHR (Rel homology region).
4.2 Class: STAT
4.3 Class: p53
4.4 Class: MADS box
4.5 Class: beta-Barrel alpha-helix transcription factors
4.6 Class: TATA-binding proteins
4.7 Class: HMG.
4.8 Class: Heteromeric CCAAT factors
4.9 Class: Grainyhead
4.10 Class: Cold-shock domain factors
4.11 Class: Runt

0 Superclass: Other Transcription Factors

0.1 Class: Copper fist proteins
0.2 Class: HMGI(Y)
0.3 Class: Pocket domain
0.4 Class: E1A-like factors
0.5 Class: AP2/EREBP-related factors